Chromatin Structure & Function

The Chromatin Structure and Function Gordon Conference covers all aspects of chromatin organization and its impact on nuclear processes, such as gene expression and DNA repair. Themes include:

* The folding of nucleosomal arrays into higher orde...

The Chromatin Structure and Function Gordon Conference covers all aspects of chromatin organization and its impact on nuclear processes, such as gene expression and DNA repair. Themes include:

* The folding of nucleosomal arrays into higher order structures and the role of linker histones and of core histone variants
* Chromatin assembly at the replication fork, in association with repair of damaged DNA and within highly transcribed genes where chromatin is disrupted by the passage of RNA polymerase
* Energy-dependent transitions of nucleosome structure, the relocation and disassembly of nucleosomes and the ATP-dependent exchange of histone variants
* Signals that converge in a combinatorial pattern of chemical histone modifications and their interpretation by interacting factors
* The requirements for transcription initiation as well as elongation in a chromatin context
* The generation of silent states by reinforcing positive feed-back loops, as a hallmark of heritable, epigenetic gene silencing that occurs normally during development, but also erroneously in some tumours
* Dosage compensation systems that coordinate the expression of all individual genes of a complex eukaryote through modulation of chromatin structure
* The rules that govern the arrangements of chromosomes within the nucleus and the compartmentalisation of nuclei into functional domains

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